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Journal: Current Issues in Molecular Biology
Article Title: Alleviation of Aflatoxin B1-Induced Hepatic Damage by Propolis: Effects on Inflammation, Apoptosis, and Cytochrome P450 Enzyme Expression
doi: 10.3390/cimb48010056
Figure Lengend Snippet: Evaluation of various biochemical parameters in liver tissues. IL-1β: Interleukin-1β ( a ), IL-6: Interleukin-6 ( b ), TNF-α: Tumor necrosis factor-α ( c ), Nrf2: Nuclear factor erythroid 2-related factor ( d ), HO-1: Heme oxygenase-1 ( e ). Data are expressed as mean ± SD (n = 6 per group). One-way ANOVA followed by Tukey’s post hoc test was used to analyze the data. * p < 0.05, ** p < 0.001 indicates statistical significance. TNF-α levels showed no significant differences among the groups.
Article Snippet: Additionally, levels of nuclear factor erythroid 2-related factor 2 (Nrf2; Cat. No: E1083Ra) and
Techniques:
Journal: Journal of Dental Sciences
Article Title: Nuclear factor erythroid 2-related factor 2/heme oxygenase-1 activation by nattokinase reduces pro-inflammatory and matrix-degrading mediators in human gingival fibroblasts
doi: 10.1016/j.jds.2025.10.022
Figure Lengend Snippet: Nattokinase suppresses COX-2 and MMP-1 via Nrf2/HO-1 activation. Cells were pretreated with ML385 or Heme Oxygenase-1-IN-1 hydrochloride (HO-1i) for 1 h, with or without nattokinase, followed by PM exposure. (A) COX-2 protein expression, (B) PGE 2 release, and (C) MMP-1 release were examined. Cells were treated for different time points, and (D) HO-1 mRNA levels and (E) ARE-luciferase activity were examined. Data are presented as mean ± SD from at least three independent experiments. # P < 0.01 compared with cells treated with PM plus nattokinase (A–C). ∗ P < 0.05, # P < 0.01 compared with the control group (D and E). COX-2: cyclooxygenase-2; MMP-1: matrix metalloproteinase-1; Nrf2: nuclear factor erythroid 2-related factor 2; HO-1: heme oxygenase-1; PM: particulate matter; PGE 2 : prostaglandin E 2 ; HO-1i: heme oxygenase-1 inhibitor; ARE: antioxidant response element.
Article Snippet:
Techniques: Activation Assay, Expressing, Luciferase, Activity Assay, Control